Vitamin D - a key to reducing the risk of suicide?

Jacek  Januszewski; Alicja  Forma; Kaja Hanna  Karakuła; Ryszard  Sitarz; Jacek  Baj; Karolina  Kłodnicka; Julita  Zembala; Dariusz  Juchnowicz

doi:10.12923/2353-8627/2023-0015

Autor

Jacek Januszewski Department of Forensic Medicine, Medical University of Lublin, Poland Autor https://orcid.org/0000-0003-1023-4081
Alicja Forma I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, Poland Autor https://orcid.org/0000-0001-8714-7627
Kaja Hanna Karakuła I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, Poland Autor https://orcid.org/0000-0003-1493-8502
Ryszard Sitarz I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, Poland Autor https://orcid.org/0000-0001-7503-1838
Jacek Baj Department of Anatomy, Medical University of Lublin, Poland Autor https://orcid.org/0000-0002-1372-8987
Karolina Kłodnicka Department of Anatomy, Medical University of Lublin, Poland Autor
Julita Zembala University Clinical Center, Medical University of Warsaw, Poland Autor
Dariusz Juchnowicz Department of Psychiatry and Psychiatric Nursing, Medical University of Lublin, Poland Autor https://orcid.org/0000-0003-2027-5469

DOI:

https://doi.org/10.12923/2353-8627/2023-0015

Słowa kluczowe:

witamina D, suplementacja witaminy D, samobójstwo, zaburzenia psychiczne

Abstrakt

Wstęp: Witamina D ma duży pozytywny wpływ na ludzkie zdrowie. Jej codzienna suplementacja reguluje metabolizm wapnia, procesy zapalne i neuromodulatorowe. Co ważniejsze, witamina D może być istotnym czynnikiem zmniejszającym ryzyko samobójstwa wśród pacjentów psychiatrycznych. Niniejszy przegląd ma na celu opisanie potencjalnego pozytywnego wpływu suplementacji witaminą D na zapobieganie próbom samobójczym.

Materiał i metody: Przegląd literatury został przeprowadzony poprzez wyszukiwanie artykułów w języku angielskim i polskim w PubMed, Medline i Google Scholar, opublikowanych w okresie od 1974 roku do 1 kwietnia 2023 roku, zgodnie z wymogami SANRA. W wyszukiwaniu wykorzystano następujące słowa kluczowe: witamina D, niedobór witaminy D, suplementacja witaminy D, samobójstwo, depresja, choroba afektywna dwubiegunowa, schizofrenia, ADHD, lęk i autyzm. Analiza obejmowała oryginalne badania, metaanalizy, randomizowane badania kontrolowane i artykuły przeglądowe.

Wyniki: Istnieje ograniczona liczba badań dotyczących wpływu suplementacji witaminą D na ryzyko samobójstwa u osób z chorobami psychicznymi. Kilka badań sugeruje, że witamina D może mieć korzystny wpływ na objawy chorób psychicznych. Jednak dokładny mechanizm, poprzez który witamina D wywiera swój terapeutyczny wpływ na zdrowie psychiczne, pozostaje niejasny. Włączenie witaminy D do leczenia zaburzeń psychicznych, takich jak depresja, schizofrenia, choroba afektywna dwubiegunowa, ADHD, zaburzenia ze spektrum autyzmu i stany lękowe, a także jej suplementacja w czasie ciąży i przez całe życie, może być potencjalnie skutecznym dodatkiem terapeutycznym w podejściu do zapobiegania samobójstwom.

Konkluzja: Według wszystkich zebranych badań i danych istnieje korelacja między suplementacją witaminą D a zmniejszeniem ryzyka samobójstwa wśród pacjentów cierpiących na zaburzenia psychiczne. Analiza wykazała pozytywny wpływ witaminy D na zdrowie psychiczne u pacjentów cierpiących na choroby psychiczne. Konieczne są jednak dalsze badania w celu ustalenia mechanizmów terapeutycznego działania witaminy D.

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Vitamin D - a key to reducing the risk of suicide?

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