Is there any association between manganese level and schizophrenia?- a descriptive review

Dariusz  Juchnowicz; Kaja Hanna  Karakuła; Elżbieta  Sitarz; Alicja  Forma; Olga  Padała; Aleksander Janusz  Ryczkowski

doi:10.2478/cpp-2020-0005

Autor

Dariusz Juchnowicz Department of Psychiatric Nursing, Medical University of Lublin, Poland Autor https://orcid.org/0000-0003-2027-5469
Kaja Hanna Karakuła Student Scientific Club at the I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, Poland Autor https://orcid.org/0000-0003-1493-8502
Elżbieta Sitarz I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, Poland Autor https://orcid.org/0000-0001-7503-1838
Alicja Forma Student Scientific Club at the Department of Forensic Medicine, Medical University of Lublin, Poland Autor https://orcid.org/0000-0001-8714-7627
Olga Padała I Department of Psychiatry, Psychotherapy, and Early Intervention, Medical University of Lublin, Poland Autor https://orcid.org/0000-0003-1469-0877
Aleksander Janusz Ryczkowski St. John of God Independent Public Provincial Hospital in Lublin, Poland Autor https://orcid.org/0000-0003-2917-0030

DOI:

https://doi.org/10.2478/cpp-2020-0005

Słowa kluczowe:

schizofrenia,, mangan, Mn

Abstrakt

Wstęp: Mangan odgrywa ważną rolę w transporcie przez błony komórkowe, syntezie białka, witaminy C i witamin B, katalizie hematopoezy, regulacji układu hormonalnego, układu odpornościowego, poziomu cukru we krwi, układzie rozrodczym, trawieniu i krzepnięciu krwi. Ponadto wydaje się, że poziom manganu ma związek z występowaniem schizofrenii. Celem tego artykułu było poszukiwanie związków pomiędzy poziomem Mn a występowaniem schizofrenii.

Materiał i metoda: Przegląd literatury przeprowadzono na podstawie przeszukiwania artykułów w Medline i Google Scholar od 2003 do 2020 r., używając słów kluczy: schizofrenia; mangan; Mn. Uwzględniono badania, które obejmowały metaanalizy, badania kontrolowane i badania kohortowe, w których badano różnice stężeń manganu u pacjentów ze schizofrenią i zdrowych osób.

Wyniki: Do przeglądu wybrano osiem badań, z których jedno wykazało podwyższony poziom manganu, dwa nie wykazały istotnych zmian, a pozostałe wraz z dwoma metaanalizami stwierdziły obniżone stężenie manganu u pacjentów ze schizofrenią niż w grupie kontrolnej.

Bibliografia

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Czy istnieje związek między poziomem manganu a schizofrenią? - artykuł przeglądowy

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