The importance of the immune system in the pathogenesis of affective disorders
Keywords:
affective disorders, the immune system, cytokinesAbstract
Affective disorders have been associated with immune system imbalance due to increased excretion of proinflammatory cytokines. Significant levels of interleukin-1, interleukin-6 and tumour necrosis factor alpha play an important role in the pathogenesis of psychiatric disorders such as depression and bipolar disorder. Nowadays, the molecular impact of these factors on the cells remains poorly understood. This is partly due to differences in clinical phenotypes of the diseases and the complex interactions between genetic and cellular factors.
Some studies showed that abnormalities of the immune system in psychiatric disorders are located at the periphery and in the brain. Activation of certain cells of the immune system has been implicated with overexpressed inflammatory factors, which may be a key role in brain dysfunction.
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