Znaczenie stresu oksydacyjnego w patogenezie i leczeniu choroby afektywnej dwubiegunowej: przegląd literatury
DOI:
https://doi.org/10.12923/2353-8627/2024-0018Słowa kluczowe:
stres oksydacyjny, choroba afektywna dwubiegunowa, redox, peroksydacja lipidów, uszkodzenia białek, antyoksydantyAbstrakt
Wstęp: Zaburzenie afektywne dwubiegunowe (ChAD), znane również jako choroba maniakalno-depresyjna, jest przewlekłym i nawracającym zaburzeniem psychicznym charakteryzującym się znacznymi zaburzeniami nastroju. Jest to jedna z głównych przyczyn niepełnosprawności na świecie i wiąże się z wysokim ryzykiem samobójstwa. Ostatnie badania podkreślają rolę stresu
oksydacyjnego (OS) w patogenezie ChAD. Zaburzenie równowagi pro/antyoksydacyjnej organizmu wpływają niekorzystnie na procesy komórkowe i molekularne.
Cel: Celem niniejszego przeglądu jest synteza obecnego stanu wiedzy na temat roli OS w etiologii i przebiegu ChAD, z uwzględnieniem kluczowych biomarkerów oraz potencjalnych interwencji terapeutycznych.
Metody: Przeprowadzono przegląd literatury naukowej, obejmujący artykuły opublikowane w latach 2000–2024. Wyszukiwanie przeprowadzono w bazach danych PubMed, Scopus oraz Web of Science, wykorzystując następujące słowa kluczowe: „bipolar disorder”, „oxidative stress”, „antioxidants”, „biomarkers”, „mitochondrial dysfunction”, „redox homeostasis”, „treatment”.
Wyniki: Wyniki wskazują, że u pacjentów z ChAD obserwuje się podwyższone poziomy markerów OS, w tym zwiększoną peroksydację lipidów, zmienioną aktywność enzymów antyoksydacyjnych oraz zaburzenia homeostazy redoks. Leczenie litem i innymi stabilizatorami nastroju może modulować poziomy wskaźników OS, co jest jednym z potencjalnych mechanizmów działania leków. Jednakże niejednoznaczne dane sugerują potrzebę dalszych badań w celu wyjaśnienia związku między OS a ChAD.
Wnioski: OS odgrywa istotną rolę w patofizjologii ChAD, oferując potencjalne kierunki dla interwencji terapeutycznych. Zrozumienie złożonych interakcji między OS a ChAD może prowadzić do opracowania bardziej ukierunkowanych terapii, mających na celu redukcję uszkodzeń oksydacyjnych i poprawę stanu zdrowia pacjentów.
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