Mechanisms of pathological changes development in periodontium tissues during long-term omeprazole administration

Authors

  • Anna Manko Higher State Educational Institution of Ukraine Ukrainian Medical Stomatological Academy, Medical, Physical-Colloidal, Bioorganic and Biological Chemistry Department, Ukraine Author
  • Javad Ghasemzadeh Higher State Educational Institution of Ukraine Ukrainian Medical Stomatological Academy, Medical, Physical-Colloidal, Bioorganic and Biological Chemistry Department, Ukraine Author

Keywords:

periodontium, omeprazole, hypoacidity, hypergastrinemia

Abstract

Under the long-term administration of omeprazole pathological changes appear in soft periodontium tissues, namely: disbalance of NO-ergic system, activation of free-radical oxidation, increase of MMM concentration, activation of MMP-1 and, consequently, intensification of collagen proteins destruction and increase of catabolism of connective tissue amorphous phase components of periodontium.

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Published

2010-12-30

Issue

Vol. 23 No. 4 (2010): Annales UMCS, Pharmacia, Sectio DDD, Volume XXIII

Section

Artykuły

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